Plasma cysteine/cystine redox couple disruption in animal models of temporal lobe epilepsy

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Plasma cysteine/cystine redox couple disruption in animal models of temporal lobe epilepsy

Currently the field of epilepsy lacks peripheral blood-based biomarkers that could predict the onset or progression of chronic seizures following an epileptogenic injury. Thiol/disulfide ratios have been shown to provide a sensitive means of assessing the systemic redox potential in tissue and plasma. In this study, we utilized a rapid, simple and reliable method for simultaneous determination ...

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  Epilepsy is one of the most common chronic disorders affecting individuals of all ages. A greater understanding of pathogenesis in epilepsy will likely provide the basis fundamental for development of new antiepileptic therapies that aim to prevent the epileptogenesis process or modify the progression of epilepsy in addition to treatment of epilepsy symptomatically. Therefore, severa...

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ژورنال

عنوان ژورنال: Redox Biology

سال: 2016

ISSN: 2213-2317

DOI: 10.1016/j.redox.2016.05.004